Liver Enzymes in Dogs. Liver Tumors and Cancers in Dogs and Cats. Localized Demodectic Mange in Dogs. Lung Cancer in Dogs and Cats. Lupoid Onychodystrophy in Dogs. Lyme Disease in Dogs. Lymphocytic Leukemia in Dogs. Lymphoma in Dogs. Lymphoma in the Skin of Dogs.
Malassezia Otitis in Dogs and Cats. Malignant Melanoma in Dogs and Cats. Malignant Thyroid Tumors in Dogs and Cats. Mammary Tumors in Dogs. Managing Megaesophagus in Dogs. Mast Cell Tumors in Dogs and Cats. Masticatory Myositis Eosinophilic Myositis in Dogs. Medial Luxating Patella in Dogs. Megaesophagus in Dogs. Meibomian Gland Eyelid Tumors in Dogs. Meibomian Gland Tumors in Dogs. Meningioma in Dogs and Cats. Mitral Valve Disease in Dogs and Cats.
Monitoring Glucose Regulation in Dogs and Cats. MRSA vs. Multiple Myeloma in Dogs and Cats. Mushroom Poisoning in Dogs and Cats. Myasthenia Gravis in Dogs and Cats.
Nasal Squamous Cell Carcinoma in Cats. Neuropathic Pain in Dogs and Cats. Osteosarcoma in Dogs. Otitis Externa Treatment in Dogs. Ovarian Remnant Syndrome in Dogs and Cats. Pacemakers in Dogs and Cats. Pancreatitis in Dogs. Pannus in Dogs. Panosteitis: Growing Pains in Dogs. Paralyzed Dogs: How to Care for Them. Parvovirus in Dogs. Parvovirus Infection: Diagnosis. Parvovirus Infection: Physical Illness and Treatment. Parvovirus: Basic Virology.
Parvovirus: Caring for the Recovered Dog. Parvovirus: How it Happens. Parvovirus: Vaccination and Prevention. Patellar Luxation in Dogs Ranges in Severity. Patent Ductus Arteriosus in Dogs and Cats.
Pemphigus Foliaceus in Dogs and Cats. Perianal Fistulae in Dogs. Physaloptera Stomach Worm in Dogs and Cats. Physical Rehabilitation for Arthritis in Dogs. Pituitary Macroadenoma in Cushing's Syndrome. Pneumonia Management in Dogs and Cats. Pneumothorax in Dogs and Cats.
Portal Vein Hypoplasia in Dogs and Cats. Portosystemic Shunt in Dogs and Cats. Positive Snap Tests for Ehrlichia and Anaplasma. Prostate Cancer in Dogs. Protruding Vaginal Masses in Dogs. Pruritus Diagnostics in Dogs and Cats. Pulmonary Hypertension in Dogs and Cats.
Pulmonic Stenosis in Dogs and Cats. Pyelonephritis in Dogs and Cats. Pyoderma in Dogs and Cats. Pyometra in Dogs and Cats. Pyothorax in Dogs and Cats. Rabies in Animals. Rectal Prolapse in Dogs and Cats. Renal Failure Dietary Therapy. Rhinitis in Dogs and Cats. Ringworm in Dogs and Cats.
Rocky Mountain Spotted Fever in Dogs. Salivary Mucocele in Dogs and Cats. Salmon Poisoning in Dogs. Sanitizing and Disinfecting the Environment after Parvovirus in Dogs. Sarcoptic Mange Scabies in Dogs. Sarcoptic Mange in Dogs. Schnauzer Comedone Syndrome.
Scottie Cramp in Dogs. Seasonal Flank Alopecia in Dogs. Sebaceous Adenitis in Dogs. Seborrhea in Dogs. Seizure Disorders in Dogs. Senility in Dogs. Senior Dog Health Issues. Shar Pei Recurrent Fever Syndrome. Splenic Masses in Dogs Splenectomy. Spondylosis Deformans in Dogs and Cats.
Steroid Use in Dogs and Cats. Strangles in Puppies. Subaortic Stenosis in Dogs. Swimmer's Ear in Dogs. Symptoms of Cushing's Syndrome. Syringomyelia in Dogs. Testicular Cancer in Dogs.
Tetanus in Pets Lock Jaw. The Wrath of Grapes. Thrombocytopenia in Dogs and Cats. Tooth Resorption in Dogs.
Tracheal Collapse in Dogs. Transitional Cell Carcinoma in Dogs and Cats. Transmissible Venereal Tumors in Dogs. Treatment of Pituitary Form of Cushing's Syndrome. Tremoring or Shivering in Dogs. Umbilical Hernias in Puppies and Kittens. Urinary Incontinence in Dogs and Cats. Uveitis in Dogs and Cats. Vaccine Allergic Reactions in Dogs and Cats.
Vaginitis in Puppies. Valley Fever Coccidioidomycosis in Dogs and Cats. Vestibular Disease in Dogs and Cats. Viral Papillomas of Dogs. Vomiting or Regurgitation in Dogs and Cats? Von Willebrand's Disease in Dogs. Wound Care for Pets. Yeast Dough Dangers in Pets. Care and Husbandry. Abdominal Ultrasounds in Pets. Air Travel with Your Pets. Alternative Diets for Dogs and Cats. Antibiotic Use in Pets. Bad Breath in Dogs and Cats.
Bandaging: First Aid. Behavior Supplements in Dogs and Cats. Birthing Puppies. Bleeding: First Aid. Blood Work is a Basic Evaluation Tool. Brushing your Dog's Teeth.
Burns: First Aid. Can't Breathe: First Aid. CBD Use in Pets. Chemical Injuries: First Aid. Choking: First Aid. Dehydration: First Aid.
Dental Home Care for Dogs and Cats. De-Skunking Your Dog or Cat. Diarrhea and Vomiting: First Aid. Difficult Birth: First Aid. Drowning or Near Drowning: First Aid. Electrocution: First Aid. Epulis Tumor in Dogs' Mouths. Esophagostomy Tube E-tube Care. Euthanasia of Companion Animals. Eye Injuries: First Aid. Fainting and Dizziness Syncope : First Aid. False Pregnancy in Dogs. Feeding Tubes for Dogs and Cats. Fever: First Aid.
Flash Glucose Monitoring in Cats and Dogs. Fleas: Know your Enemy. Fractures and Injuries: First Aid. How Does Anesthesia Work? Hyperthermia Heat Stroke : First Aid.
Hypothermia: First Aid. Impalement and Penetrating Injuries: First Aid. Intervention for Choking in an Unconscious Dog. Keeping your Pet Healthy and Happy. Low Stress Toothbrushing for Dogs.
Microchipping Could Save your Pet's Life. Nebulizer Use for Dogs and Cats. Neutering your Male Dog. Nosebleed: First Aid. Nutrition and Exercise for Growing Puppies. Obesity is Unhealthy in Dogs and Cats. Omega Three Fatty Acids for our Pets. Oral Joint Health Supplements 2. Orthodontics for Pets. Pain Reliever Facts for Dogs and Cats. Paralysis: First Aid. Periodontal Disease in Dogs and Cats.
Periodontal Disease in Pets. Pet Insurance Fact Sheet. Pet Treats What to Look out for. Pilling Dogs and Cats. Poisoning in Dogs and Cats. Post-Operative Care for Pets. Pregnancy Termination in Dogs and Cats. Pregnant Dog Care. Rattlesnake Bites in California. Reverse Sneezing in Dogs. Roundworms in Dogs and Puppies. Runny Eyes Epiphora in Dogs.
Ruptured Cranial Cruciate Ligaments in Dogs. Safe Toys for Puppies. Seizures and Convulsions: First Aid. Shar-pei Special Needs and Cautions.
Shock: First Aid. Snake Bite Prevention and Treatment for Dogs. Snakebite: First Aid. Spaying your Female Dog. Straining to Eliminate: First Aid. Sunburn: First Aid. Sunscreen for Pets. Taenia Species Tapeworms in Dogs and Cats. Tapeworms Dipylidium caninum in Dogs and Cats. Tick Paralysis in Pets. Ticks Are Arthropod Parasites for Mammals. Toothbrushing and Dental Prophylaxis in Cats and Dogs.
Transporting an Injured Pet: First Aid. Traveling with Pets. Treating your Yard for Fleas and Ticks. Vaccine Titers for Pets. Weight Loss in Dogs.
Whipworm Infection in Dogs and Cats. Wound Healing in Dogs and Cats. Wounds: First Aid. Wrapping Up First Aid. Alcohol Poisoning. Cannabis Toxicity in Dogs. Chocolate Toxicity in Dogs. Chocolate Toxicity Signs in Dogs. Common Household Items can Poison Pets. Electronic Cigarettes are Toxic to Pets.
Ibuprofen Toxicity in Dogs and Cats. Lead Poisoning in Dogs and Cats. Nicotine Poisoning in Pets. Poisonous Plants for Dogs and Cats. Rat Poison's Effect on Dogs and Cats.
Safe and Toxic Garden Plant Images. Safe Gardening for Dogs and Cats. Snail Bait Poisoning in Dogs. Toxic and Non-toxic Plants. Winter Holiday Hazards for Pets. Xylitol Poisoning in Dogs. Zinc Poisoning in Dogs and Cats. Adopting a Shelter Dog. Aggression Between Familiar Dogs. Applying a Muzzle to an Aggressive Dog. Barking Problems in Dogs.
Behavior and the Senior Dog. Bite Levels in Dogs. Body Language of Dogs. Car Ride Anxiety in Dogs and Cats.
Desensitizing Your Dog to a Muzzle. Destructive Chewing by Puppies and Dogs. Dog Training: How to Use Rewards. Dog Training: Why to Use Rewards. Not from the FDA, whose job it is to ensure drug safety. In a prepared statement, Elanco told The Indianapolis Star: "It's critically important to understand that reports are not an indication of cause.
For any given Adverse Drug Event report, there is no certainty that the reported drug caused the adverse event. The company said it completed a "thorough review and analysis" earlier this year of all reports it received from pet owners and found "no established link between Trifexis use and death.
It said such complaints are so infrequent that it has received less than one reported death for every 10, doses it sold, which is considered "very rare," according to standards published by the Council of International Organizations of Medical Sciences. Yet, in the first examination by a major news organization of one of the fastest-growing segments of the pharmaceutical industry, The Star found an industry far different from the human drug market, one with higher risk of unforeseen side effects, a legal arena that offers little protection to pet owners and marketing tactics that have been eliminated from the human drug market.
The Star examined public records, studies and drug reaction data, and conducted interviews with company officials, pet owners, scientists, lawyers, epidemiologists, regulators and veterinarians. They told the story of an industry that is looking for ways to shore up declining revenues from human drugs, repurposing molecules that had an array of original uses for people and crops, and pushing government officials to speed up the approval process.
Drug and medical-device companies are pouring millions of dollars a year into research and development of pet medicines, hoping they can help make up the difference for a slowdown in human drug approvals. There are specialized animal drugs for everything from arthritis and heart disease to obesity and kidney disease. Last year, the third-biggest initial public offering on Wall Street was a pet medicine company, Zoetis, a spinoff from drug giant Pfizer.
Yet the pace of change is raising safety concerns among thousands of pet owners, consumer groups and some veterinarians across the country. The drug-development process for pet medicines is far shorter than for human drugs, which cuts costs but increases the health risks to the animals, several epidemiologists and statisticians told The Star. Once these drugs are released on the market, there are few checks on company claims of product safety. Some drugs aren't even approved for animal use but are commonly prescribed to animals.
Their safety record isn't even tracked by the government, meaning it's impossible for consumers to make informed decisions. And when animals die, the companies don't have to shell out big legal settlements.
While drug companies have paid billions of dollars to settle complaints about human drugs, they sometimes resolve consumer complaints about pet medicines with polite letters and payments not even large enough to cover the cost of veterinary treatment. Dozens of human drugs have been removed from the market because of safety concerns, but The Star was unable to find a single pet drug that was permanently pulled for similar reasons. The message is clear: A dog is just a dog, and a cat is just a cat.
And industry lawyers are fighting to keep it that way. Still, the industry's marketing departments are sending a different message: "Your pet is a member of the family. Studies show pet owners who share that view spend more than twice as much on veterinary care.
All this creates a marketplace where independent information is scarce and drug company money plays a role in outside research, continuing education and regulatory review. In stark contrast to the world of human medicine, veterinarians, researchers and industry are free to work closely together, with little to no transparency about drug company freebies and speaking fees paid to veterinarians.
Such undisclosed payments have been all but banned from the human drug market, where too much is at stake to risk even the appearance of bias in medical decisions. A friend, who was staying in his house in Noblesville, was on the line. She was watching Surtani's two dogs while he was on winter vacation in Texas with his wife, Laura, and two sons. Something was wrong with Sesame, Surtani's pound golden doodle, the friend said.
The dog had awakened her to go out, then collapsed on the patio. He couldn't stand up. The day before, Sesame had vomited twice and was wobbly, the friend said. Now she was rushing the dog to an emergency vet clinic nearby. When Surtani reached the vet on the phone, she told him Sesame was alert and seemed to be stable, although his heart rate was a bit high and his blood sugar was a little low.
She didn't see anything that would explain his sudden inability to walk, such as signs of a heart attack, a rupture or bleeding, Surtani recalled. Surtani, who earned a medical degree from the University of Texas in , couldn't stop himself from trying to diagnose the situation.
Sesame's early lab results showed his kidney function was fine. Blood count was normal. One of the liver functions was slightly elevated. Surtani, a surgeon, wondered if his dog might have a serious gastrointestinal problem that would require an emergency operation.
Sometimes big dogs will eat something strange — a sock or a hat — and get their intestines twisted. He asked the vet to prepare the dog for surgery, just in case. Surtani, who described himself as "pretty frantic," said go ahead. He hung up, wondering about other possible causes.
Both of Surtani's golden doodles, Sesame and Cricket, had been completely healthy. The Surtanis had gotten them eight years earlier as pups.
They had undergone no surgeries, aside from being neutered seven years earlier. The family walked the dogs every day, usually four or five miles. They loved to run, leap and play with Surtani's boys, Nels and Tate. Sesame was affectionate, never bit anyone, was the "star of the class" in obedience school, Surtani said, a "very regal dog. Just a month before he died, Sesame had had his teeth cleaned, a procedure that included putting him under a general anesthetic so he wouldn't nip the veterinarian.
He had come out of it fine. On the phone with the emergency veterinarian, Surtani learned that Sesame hadn't responded to CPR, nor to epinephrine, an emergency drug used to treat patients after a heart attack. The veterinarian had taken X-rays in search of more clues. She didn't see anything wrong with the heart.
The lungs were perfect. There was nothing abnormal in the belly. In short, the veterinarian didn't have an answer. She apologized and asked Surtani to wait for the animal surgeon, who would be arriving shortly. An hour or so later, the surgeon called. After a brief chat, he asked for permission to conduct an autopsy, an unusual and costly step in a dog's death. Surtani consented. He wanted an answer. When the veterinary surgeon called Surtani back, he said he had cut open Sesame's abdomen.
There was nothing unusual aside from an adrenal gland that was a little larger and firmer than usual. Maybe Sesame had some sort of adrenal tumor, the surgeon said, that may have shot out adrenaline and killed the dog, a condition called pheochromocytoma.
Surtani didn't know about that. The dog's heart hadn't been racing. His exertion was normal. There was no evidence he had pheochromocytoma. Across the country, pet owners were having similar experiences, and suspicions were rising about a new flea and heartworm medicine — Trifexis, which was developed by Lilly's animal drug unit, Elanco, and is now a top-selling pet medicine.
Eamonn Kneeshaw of Clearwater, Fla. After his first dose in May , Harry vomited and refused his favorite foods. His back legs went out. Rebecca Haaland of Scott, La. Six months later, he was dead.
The vet said the dog must have gotten into something. The enzymes in his liver were extremely high. Lou Gallo of Radford, Va. A month later, Peaches was dead. Although there is no proven link between the deaths and Trifexis, some bereaved pet owners, fearing the drug had killed their dogs, mobilized to get the word out.
Kneeshaw drives a Hummer with huge letters in the back window: "Warning: Trifexis killed my dog and is killing many more every day.
Scores of people have posted similar stories on the page. By last month, the site had more than 6, "likes. Gallo's Facebook page lists a handful of animal clinics, from New York to California, that refuse to carry Trifexis.
One of her technicians got a free sample and gave it to her dog, and it had seizures, Tressler said. Rising professional Early-career resources to continue your professional and personal growth. Diversity, equity, and inclusion Creating socially conscious work environments. Wellbeing Self-care and workplace wellbeing for the whole veterinary team. Practice management Profitability and finance, marketing, leadership, and team building.
Personal finances Loans, budgets, financial planning, and more. One Health Interprofessional collaboration across animal, human, and environmental health. Public resources Pet owners K educators.
0コメント