With continued use, tolerance to hydrocodone can develop, and with increased dosage, there may be increased side effects. People who previously exhibited hypersensitivity to hydrocodone or acetaminophen should not take medications with these active ingredients.
It should always be remembered that there is the potential for respiratory depression and that the drug suppresses the cough mechanism. The drug can be habit-forming. If you require increasingly more medicine to achieve the same therapeutic benefit, talk to your healthcare provider. Its use during pregnancy may lead to physical dependence or breathing problems in the newborn. There may be drug interactions with narcotic analgesics and antihistamines, antipsychotics, anti-anxiety medications, or other central nervous system depressants, including alcohol and sedatives.
Signs and symptoms of overdose include respiratory depression, extreme sleepiness that progresses to coma, skeletal muscle flaccidity limpness , cold or clammy skin, bradycardia slow heartbeat , and hypotension low blood pressure.
With very severe overdose, there can be apnea, circulatory collapse, cardiac arrest, and death. The acetaminophen portion can result in fatal hepatic necrosis, renal tubular necrosis, hypoglycemic coma, and thrombocytopenia low platelets. Dealing with chronic inflammation? An anti-inflammatory diet can help. Our free recipe guide shows you the best foods to fight inflammation. Get yours today! Food and Drug Administration. FDA drug safety communication: Prescription acetaminophen products to be limited to mg per dosage unit; boxed warning will highlight potential for severe liver failure.
Updated February 7, DailyMed U. National Library of Medicine. Label: Hydrocodone bitartrate and acetaminophen tablet. Updated May 29, Hydrocodone combination products. Updated January 15, Hydrocodone and acetaminophen overdose. Updated October 8, Your Privacy Rights. To change or withdraw your consent choices for VerywellHealth.
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